Location: Diet, Genomics and Immunology Lab
Project Number: 1235-52000-054-00
Start Date: Apr 02, 2004
End Date: Mar 15, 2009
It is hypothesized that probiotic microbes induced a more balanced maturation of mucosal immune system. These studies are difficult to conduct in humans and an animal model to demonstrate a 'proof of principle' for the effectiveness of dietary probiotics on neonatal maturation and modulation of mucosal immunity is needed. The overall approach of this project is to identify and measure the effect of probiotics as a dietary component for early induction of mucosal immune system development in newborn swine as a model for nutrient conditioning of a balanced immune system in humans. On the basis of the epidemiological studies done with humans we predict that it will be possible to enhance development and modulate the immune system by administration of probiotics.