Projects

INTERVENTION STRATEGIES TO SUPPORT THE GLOBAL CONTROL AND ERADICATION OF FOOT-AND-MOUTH DISEASE VIRUS (FMDV) Appropriated (D)   Accession Number: 422203

VIRAL DETERMINANT OF PATHOGENESIS AND VIRULENCE: A STUDY MODEL BASED ON THE FMDV OUTBREAK STRAIN A ARGENTINA 2001 Nonfunded Cooperative Agreement (N)   Accession Number: 419636

COUNTERMEASURES FOR FOOT-AND-MOUTH DISEASE UTILIZING DIAGNOSTICS, BIOTHERAPEUTICS, A NOVEL VACCINE PLATFORM AND IMPROVED CHALLENGE SYSTEMS Reimbursable (R)   Accession Number: 421628

FOOT-AND-MOUTH DISEASE VIRUS (FMDV) STRAIN CHARACTERIZATION Specific Cooperative Agreement (S)   Accession Number: 421661

FOOT-AND-MOUTH DISEASE MONOCLONAL ANTIBODIES PRODUCTION IN CAMELS Specific Cooperative Agreement (S)   Accession Number: 421368

ANTIGENIC PROFILING AND GENETIC ANALYSIS OF FOOT-AND-MOUTH DISEASE VIRUS IN UGANDA Specific Cooperative Agreement (S)   Accession Number: 421550

ANTIGENIC STRUCTURE OF FMDV CAPSID PROTEINS AND THE SELECTION OF APPROPRIATE CANDIDATE VACCINE STRAINS IN EMERGING FMD OUTBREAKS Specific Cooperative Agreement (S)   Accession Number: 418615

Development of Novel Foot-and-Mouth Disease Virus with Multiple Mutations for Evaluation as Live Attenuated Diva Vaccine Candidate Trust (T)   Accession Number: 424159

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Repeated exposure to 5D9, an inhibitor of 3D polymerase, effectively limits the replication of Foot-and-Mouth Disease Virus in host cells. - (Peer Reviewed Journal)

Rai, D.K., Schafer, E.A., Singh, K., Mcintosh, M., Sarafianos, S., Rieder, A.E. 2013. Repeated exposure to 5D9, an inhibitor of 3D polymerase, effectively limits the replication of Foot-and-Mouth Disease Virus in host cells. Antiviral Research. 98(3):380-385 DOI:10.1016/j.antiviral.2013.03.022.

Analysis of SAT type foot-and-mouth disease virus capsid proteins and the identification of putative amino acid residues in virus stability - (Peer Reviewed Journal)

Maree, F.F., Blignaut, B., De Beer, T.A., Rieder, A.E. 2013. Analysis of SAT type foot-and-mouth disease virus capsid proteins and the identification of putative amino acid residues in virus stability. PLoS One. 8(5):e61612 DOI:10.1371/journal.pone.0061612.

Structure-based discovery of foot-and-mouth disease inhibitors that target the 3Dpol RNA-dependent RNA polymerase - (Peer Reviewed Journal) - (27-Feb-13)

Examination of soluble integrin resistant mutants of foot-and-mouth disease virus (FMDV) - (Peer Reviewed Journal)

Lawrence, P., Larocco, M.A., Schafer, E.A., Baxt, B., Rieder, A.E. 2013. Examination of soluble integrin resistant mutants of foot-and-mouth disease virus (FMDV). Virology Journal. 10(1):2.

Foot-and-mouth disease virus (FMDV) with a stable FLAG epitope in the VP1 G-H loop as a new tool for studying FMDV pathogenesis - (Peer Reviewed Journal)

Lawrence, P., Uddowla, S., Pacheco Tobin, J., Kotecha, A., Fry, E., Rieder, A.E. 2012. Foot-and-mouth disease virus (FMDV) with a stable FLAG epitope in the VP1 G-H loop as a new tool for studying FMDV pathogenesis. Virology. 136(1):150-161.

Theiler’s murine encephalomyelitis virus contrasts with encephalomyocarditis and foot-and-mouth disease viruses in its functional utilization of the StopGo non-standard translation mechanism - (Peer Reviewed Journal)

Loughran, G., Libbey, J.E., Uddowla, S., Scallan, M.F., Ryan, M.D., Fujinami, R.S., Rieder, A.E., Atkins, J.F. 2013. Theiler’s murine encephalomyelitis virus contrasts with encephalomyocarditis and foot-and-mouth disease viruses in its functional utilization of the StopGo non-standard translation mechanism. Journal of General Virology. 94(2):348-353.

Homology modelling and analysis of structure predictions of the bovine rhinitis B virus RNA-dependent RNA polymerase (RdRp) - (Peer Reviewed Journal)

Rai, D., Rieder, A.E. 2012. Homology modelling and analysis of structure predictions of the bovine rhinitis B virus RNA-dependent RNA polymerase (RdRp). International Journal of Molecular Sciences. 2012(3):8998-9013.

The nuclear protein Sam68 is cleaved by the FMDV 3C protease redistributing Sam68 to the cytoplasm during FMDV infection of host cells - (Peer Reviewed Journal)

Lawrence, P.J., Schafer, E.A., Rieder, A.E. 2012. The nuclear protein Sam68 is cleaved by the FMDV 3C protease redistributing Sam68 to the cytoplasm during FMDV infection of host cells. Virology. 425:40-52.

Predicting antigenic sites on the foot-and-mouth disease virus capsid of the South African Territories (SAT) types using virus neutralization data - (Peer Reviewed Journal)

Maree, F.F., Blignaut, B., Esterhuysen, J.J., De Beer, T., Theron, J., O'Neill, H.G., Rieder, A.E. 2011. Predicting antigenic sites on the foot-and-mouth disease virus capsid of the South African Territories (SAT) types using virus neutralization data. Journal of General Virology. 92(10):2297-2309.

The pathogenesis of foot-and-mouth disease II; viral pathways in swine, small ruminants, and wildlife, myotropism, chronic syndromes, and molecular virus-host interactions - (Review Article)

Arzt, J., Baxt, B., Grubman, M.J., Jackson, T., Juleff, N., Rhyan, J., Rieder, A.E., Waters, R., Rodriguez, L.L. 2011. The pathogenesis of foot-and-mouth disease II; viral pathways in swine, small ruminants, and wildlife, myotropism, chronic syndromes, and molecular virus-host interactions. Transboundary and Emerging Diseases. 58(4):305-326.

Custom-engineered chimeric foot-and-mouth disease vaccine elicits protective immune responses in pigs - (Peer Reviewed Journal)

Blignaut, B., Visser, N., Theron, J., Rieder, A.E., Maree, F.F. 2011. Custom-engineered chimeric foot-and-mouth disease vaccine elicits protective immune responses in pigs. Journal of General Virology. 92(4):849-859.

Analysis of sat type foot-and-mouth disease virus capsid proteins: influence of receptor usage on the properties of virus particles - (Peer Reviewed Journal)

Maree, F.F., Blignaut, B., Aschenbrenner, L., Burrage, T., Rieder, A.E. 2010. Analysis of sat type foot-and-mouth disease virus capsid proteins: influence of receptor usage on the properties of virus particles. Virus Research. 155:462-472.

Sequence-based prediction for vaccine strain selection and identification of antigenic variability in foot-and-mouth disease virus - (Peer Reviewed Journal)

Reeve, R., Blignaut, B., Esterhuysen, J.J., Opperman, P., Matthews, L., Fry, E., De Beer, T.A., Theron, J., Rieder, A.E., Vosloo, W., O'Neill, H.G., Haydon, D.T., Maree, F.F. 2010. Sequence-based prediction for vaccine strain selection and identification of antigenic variability in foot-and-mouth disease virus. PLoS Computational Biology. DOI: 10.1371/journal.pcbi.1001027.

Domain disruptions of individual 3B proteins for foot-and-mouth disease virus do not alter growth in cell culture nor virulence in cattle - (Peer Reviewed Journal)

Pacheco Tobin, J., Piccone, M.E., Rieder, A.E., Pauszek, S.J., Borca, M.V., Rodriguez, L.L. 2010. Domain disruptions of individual 3B proteins for foot-and-mouth disease virus do not alter growth in cell culture nor virulence in cattle. Virology. DOI: 10.1016/j.virol.2010.05.036.

The region between the two polyprotein initiation codons of foot-and-mouth disease virus is critical for virulence in cattle - (Peer Reviewed Journal)

Piccone, M.E., Pacheco Tobin, J., Pauszek, S.J., Borca, M.V., Rieder, A.E., Kramer Jr, E.V., Zhu, J.J., Rodriguez, L.L. 2010. The region between the two polyprotein initiation codons of foot-and-mouth disease virus is critical for virulence in cattle. Virology. 396:152-159.

Identification of RNA Helicase A (RHA) as a New Host Factor in the Replication Cycle of FMDV - (Peer Reviewed Journal)

Lawrence, P.J., Rieder, A.E. 2009 Identification of RNA Helicase A (RHA) as a New Host Factor in the Replication Cycle of FMDV. Journal of Virology. 83 (21): 11356-11366.

Studies on Sam68 a cell factor involved in the life cycle of foot-and-mouth disease virus - (Abstract Only)

Lawrence, P.J., Rieder, A.E. 2009. Studies on Sam68 a cell factor involved in the life cycle of foot-and-mouth disease virus. American Society for Virology Meeting. Paper No. W36-8: p. 177.

Sequence analysis of a bovine rhinovirus type 1 strain RS3x - (Abstract Only)

Piccone, M.E., Kramer Jr, E.V., Knowles, N.J., Rieder, A.E. 2009. Sequence analysis of a bovine rhinovirus type 1 strain RS3x. American Society for Virology Meeting. Paper No. 32-8: P. 337.

Host Cell Factors Involved in the Life Cycle of FMDV - (Abstract Only)

Lawrence, P., Rieder, A.E. 2008. Host Cell Factors Involved in the Life Cycle of FMDV. European Study Group on the Molecular Biology of Picornaviruses. P 85

Role of the Region Located Between the Two AUG Initiation Codons in the Pathogenesis of Foot-and-Mouth Disease Virus (FMDV) - (Abstract Only)

Piccone, M.E., Pacheco Tobin, J., Pauszek, S.J., Borca, M.V., Rieder, A.E., Rodriguez, L.L. 2008. Role of the Region Located Between the Two AUG Initiation Codons in the Pathogenesis of Foot-and-Mouth Disease Virus (FMDV). European Study Group on the Molecular Biology of Picornaviruses. p. 199.

A Reverse Genetic System Provides a Powerful Tool in the Design of Foot-and-Mouth Disease Viruses with Enhanced Properties - (Abstract Only)

Maree, F.F., Blignaut, B., Theron, J., Visser, N., Rieder, A.E. 2008. A reverse genetic system provides a powerful tool in the design of foot-and-mouth disease viruses with enhanced properties. European Study Group on the Molecular Biology of Picornaviruses.P 202

SAT Type Foot-and-Mouth Disease (FMD) Chimeric Vaccine Elicits Protection in Pigs - (Abstract Only)

Blignault, B., Theron, J., Visser, N., Rieder, A.E., Maree, F. 2008. Sat type foot-and-mouth disease (fmd) chimeric vaccine elicits protection in pigs. European Study Group on the Molecular Biology of Picornaviruses. p. 133.

Mapping of Antigenic Sites on a SAT2 Foot-and-Mouth Disease Virus Vaccine Strain - (Abstract Only)

Opperman, P.A., Maree, F.F., Blignaut, B., Vosloo, W., Rieder, A.E., Theron, J.J. 2008. Mapping of Antigenic Sites on a SAT2 Foot-and-Mouth Disease Virus Vaccine Strain. European Study Group on the Molecular Biology of Picornaviruses. P 204

Chimeric Foot-and-Mouth Disease Viruses: Evaluation of Their Efficacy as Potential Marker Vaccines in Cattle - (Peer Reviewed Journal)

Fowler, V.L., Paton, D.J., Rieder, A.E., Barnett, P.V. 2008. Chimeric Foot-and-Mouth Disease Viruses: Evaluation of Their Efficacy as Potential Marker Vaccines in Cattle. Vaccine. 26:1982-1989.

Molecular Characterization of a Foot-and-Mouth Disease Virus (FMDV) Containing a 57-Nucleotide Insertion in the 3' Untranslated Region (3'UTR) - (Peer Reviewed Journal)

Piccone, M.E., Pauszek, S.J., Pacheco Tobin, J., Rieder, A.E., Kramer, E., Rodriguez, L.L. 2009. Molecular Characterization of a Foot-and-Mouth Disease Virus (FMDV) Containing a 57-Nucleotide Insertion in the 3' Untranslated Region (3'UTR). Archives of Virology. 154:671-676.

PATHOGENIC CHARACTERISTICS OF THE KOREAN 2002 ISOLATE OF FOOT-AND-MOUTH DISEASE VIRUS SEROTYPE O IN PIGS AND CATTLE - (Peer Reviewed Journal)

Oem, J., Yeh, M., Mckenna, T., Hayes, J.R., Rieder, A.E., Giuffre, A.C., Robida, J.M., Lee, K., Cho, I., Fang, X., Joo, Y., Park, J. 2008. Pathogenic Characteristics of the Korean 2002 Isolate of Foot-and-Mouth Disease Virus Serotype O in Pigs and Cattle. Journal of Comparative Pathology. 138(4):204-214.

Molecular and Phylogenetic Analyses of Bovine Rhinovirus Type 2 Shows it is Closely Related to Foot-and-Mouth Disease Virus - (Peer Reviewed Journal)

Hollister, J.R., Vagnozzi, A., Knowles, N., Rieder, A.E. 2008. Molecular and Phylogenetic Analyses of Bovine Rhinovirus Type 2 Shows it is Closely Related to Foot-and-Mouth Disease Virus. Virology. Vol 373/2: 411-425.

Picornaviridae - (Book / Chapter)

Rieder, A.E. 2007. Picornaviridae. Book Chapter. 2007. P523-545.

MOLECULAR ANALYSIS OF BOVINE RHINOVIRUS TYPE 2 SHOWS A CLOSE RELATIONSHIP TO THE APHTHOVIRUSES - (Abstract Only)

Hollister, J.R., Vagnozzi, A., Knowles, N.J., Rieder, A.E. 2006. Molecular Analysis of Bovine Rhinovirus Type 2 Shows a Close Relationship to the Aphthoviruses. European Study Group on the Molecular Biology of Picornaviruses (EUROPIC) 2006 Meeting, page A5.

Growth Determination for Genetic Engineered SAT Type Foot-and-Mouth Disease Viruses - (Abstract Only)

Blignaut, B., Maree, F., Theron, J., Rieder, A.E., Vosloo, W. 2006. Growth Determination for Genetic Engineered SAT Type Foot-and-Mouth Disease Viruses.European Study Group on the Molecular Biology of Picornaviruses (EUROPIC) 2006 Meeting, page B10.

Selection of Variants Utilizing Heparin Sulphate For Cell Entry When South African Territories Foot-and-Mouth Disease Virus is Adapted for Growth on Cell Culture - (Abstract Only)

Maree, F.F., Blignaut, B., Van Heerden, J., Vosloo, W., Theron, J., Rieder, A.E. 2006. Selection of Variants Utilizing Heparin Sulphate For Cell Entry When South African Territories Foot-and-Mouth Disease Virus is Adapted for Growth on Cell Culture. European Study Group on the Molecular Biology of Picornaviruses (EUROPIC) 2006 Meeting, page F14.

IN VITRO SELECTION AND ANALYSIS OF FOOT-AND-MOUTH DISEASE VIRUS RECEPTOR NEUTRALIZATION ESCAPE MUTANTS - (Abstract Only)

Rieder, A.E., Larocco, M.A., Baxt, B. 2006. In vitro selection and analysis of foot-and-mouth disease virus receptor neutralization escape mutants. American Society for Virology Annual Meeting. 2006. P 209.

ANALYSIS OF THE RECEPTOR USAGE AND GROWTH DETERMINANTS OF OUTBREAK AND VACCINE STRAINS OF SOUTH AFRICAN TERRITORIES OF FOOT-AND-MOUTH DISEASE VIRUS - (Abstract Only)

Maree, F.F., Aschenbrenner, L.M., Baxt, B., Rieder, A.E. 2006. Analysis of the receptor usage and growth determinants of outbreak and vaccine strains of south african territories of foot-and-mouth disease virus. Keystone Symposia. 2006. P. 74.

ANALYSIS OF FOOT-AND-MOUTH DISEASE VIRUS TYPE A24 ISOLATE CONTAINING AN SGD RECEPTOR RECOGNITION SITE IN VITRO AND ITS PATHOGENESIS IN CATTLE - (Peer Reviewed Journal)

Henry, T.M., Duque, H., Baxt, B., Rieder, A.E. 2005. Analysis of Foot-and-Mouth Disease Virus Type A24 Isolate Containing an SGD Receptor Recognition Site In Vitro and Its Pathogenesis in Cattle. Journal of Virology. Vol 79:20, p. 12989-12998.

DEVELOPMENT OF A MAMMALIAN CELL-FREE SYSTEM TO INVESTIGATE REPLICATION OF F00T-AND-MOUTH DISEASE AND THE ROLE OF HOST FACTORS IN VIRUS SYNTHESIS - (Abstract Only)

Rieder, A.E. 2005. Development of a Mammalian Cell-free System to Investigate Replication of Foot-and-Mouth Disease and the Role of Host Factors in Virus Synthesis. XIIIth Meeting of the European Study Group for the Molecular Biology of Picornaviruses. P.H24

RECOMBINANT ENGINEERED SAT1 FOOT-AND-MOUTH DISEASE VIRUS AS AN APPROACH TO INVESTIGATE RECEPTOR USAGE AND GROWTH DETERMINANTS OF OUTBREAK STRAINS - (Abstract Only)

Maree, F.F., Rieder, A.E. 2005. Recombinant Engineered sat1 Foot-and-Mouth Disease Virus as an Approach to Investigate Receptor Usage and Growth Determinants of Outbreak Strains. XIIIth Meeting of the European Study Group for the Molecular Biology of Picornaviruses. p 123.

NOVEL TOOLS TO PREVENT AND ERADICATE FOREIGN ANIMAL DISEASES - (Abstract Only)

Rodriguez, L.L., Baxt, B., Rieder, A.E., Golde, W.T., Borca, M.V., Grubman, M.J. 2005. Novel tools to prevent and eradicate foreign animal diseases. American Society for Microbiology Biodefense Meeting. p 41.

PHENOTYPIC AND GENETIC CHANGES IN COXSACKIEVIRUS B5 FOLLOWING REPEATED PASSAGING IN MOUSE PANCREAS IN VIVO - (Peer Reviewed Journal)

Haider, A., Davydova, B., Smura, T., Kaialainen, S., Ylipaasto, P., Saario, E., Hovi, T., Rieder, A.E., Roivainen, M. 2005. Phenotypic and genetic changes in coxsackievirus b5 following repeated passaging in mouse pancreas in vivo. Journal of Medical Virology. 75 (4), 566-574

MOLECULAR ASPECTS OF FOOT-AND-MOUTH DISEASE VIRUS VIRULENCE AND HOST RANGE: ROLE OF HOST CELL RECEPTORS AND VIRAL FACTORS - (Review Article)

Baxt, B., Rieder, A.E. 2004. Molecular Aspects of Foot-and-Mouth Disease Virus Virulence and Host Range: Role of Host Cell Receptors and Viral Factors. Foot-and-Mouth Disease: Current Perspectives. 145-172.