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ARS Home » Pacific West Area » Davis, California » Western Human Nutrition Research Center » Obesity and Metabolism Research » Research » Publications at this Location » Publication #214141
Title: Amylin and Amylin Agonists for Treating Psychiatric Diseases and Disorders

Author
item Laugero, Kevin
item HANLEY, MICHAEL - AMYLIN PHARMACEUTICALS
item MACK, CHRISTINE - AMYLIN PHARMACEUTICALS
item PARKES, DAVID - AMYLIN PHARMACEUTICALS
item YOUNG, ANDREW - AMYLIN PHARMACEUTICALS

Submitted to: Invention Report
Publication Type: Other
Publication Acceptance Date: 5/10/2006
Publication Date: 10/5/2006
Citation: Laugero, K.D., Hanley, M., Mack, C.M., Parkes, D.G., Young, A.A. 2006. Amylin and Amylin Agonists for Treating Psychiatric Diseases and Disorders. Invention Report. 2006. Patent PCT Publication No.WO 2006/105527.

Interpretive Summary: It has now been discovered that amylin, amylin agonists, amylin analogs, amylin agonist analogs, amylin derivatives, or a combination thereof, may be able to modulate the stress systems and/or the actions of CRF and/or glucocorticoids (GC), thereby presenting novel pharmacotherapeutic options. As demonstrated herein, amylin administration appears to reduce or protect against stress and it effects (e.g., anxiety, obsessive-compulsive behavior, depression, psychosis, changes in eating behavior). We also demonstrate herein that, in specific animal behavioral tests, amylin administration results in behavioral effects that include anti-stress, anxiolytic, antidepressant, and antipsychotic actions.

Technical Abstract: Methods and compositions for treating psychiatric diseases and disorders are disclosed. The methods provided generally involve the administration of an amylin or an amylin agonist to a subject in order to treat psychiatric diseases and disorders, and conditions associated with psychiatric diseases and disorders.