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ARS Home » Research » Publications at this Location » Publication #70398
Title: IN VIVO CHARACTERIZATION OF FOWLPOX VIRUS RECOMBINANT EXPRESSING THE HEXON OF HEMORRHAGIC ENTERITIS VIRUS OF TURKEYS

Author
item CARDONA, CAROL - MICHIGAN STATE UNIVERSITY
item REED, WILLIE - MICHIGAN STATE UNIVERSITY
item Silva, Robert
item Witter, Richard

Submitted to: American Veterinary Medical Association Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 7/20/1996
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: The hexon of hemorrhagic enteritis virus (HEV) is reported to be the major epitope against which neutralizing antibodies are made. The gene coding for the hexon of HEV was cloned into a fowlpox virus (FPV) vector. Experimental birds were vaccinated with this recombinant FPV(rFPV) at 4 weeks of age and challenged with virulent HEV at 6 weeks of age. The rFPV provided no protection from infection or disease with virulent HEV challenge. Antibody titers were measured pre-vaccination and weekly through the termination of the experiment. There were no detectable anti-HEV antibodies in the birds vaccinated with the rFPV prior to challenge.