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ARS Home » Plains Area » College Station, Texas » Southern Plains Agricultural Research Center » Food and Feed Safety Research » Research » Publications at this Location » Publication #310001
Title: Peptide arrays for kinome analysis of livestock species

Author
item DAIGLE, JOANNA - University Of Saskatchewan
item VAN WYK, BRENDEN - University Of Saskatchewan
item TROST, BRETT - University Of Saskatchewan
item SCRUTEN, ERIN - University Of Saskatchewan
item Arsenault, Ryan
item KUSALIK, ANTHONY - University Of Saskatchewan
item GRIEBEL, PHILLIP - University Of Saskatchewan
item NAPPER, SCOTT - University Of Saskatchewan

Submitted to: Frontiers in Veterinary Infectious Diseases
Publication Type: Review Article
Publication Acceptance Date: 6/24/2014
Publication Date: 10/14/2014
Publication URL: http://handle.nal.usda.gov/10113/60100
Citation: Daigle, J., Van Wyk, B., Trost, B., Scruten, E., Arsenault, R.J., Kusalik, A., Griebel, P., Napper, S. 2014. Peptide arrays for kinome analysis of livestock species. Frontiers in Veterinary Infectious Diseases. 1:4. doi:0.3389/fvets.2014.00004.

Interpretive Summary:

Technical Abstract: The kinases that mediate protein phosphorylation events have taken on a central priority within human medicine. This is evidenced by the number of kinase inhibitors that are currently in use as drugs as well as those advancing through clinical trials. There is also a trend to understand complex biology and identify biomarkers through characterizations of global kinase (kinome) activity. Through recent advances that enable the development of species-specific peptide arrays for kinome analysis there is considerable opportunity for similar applications and benefits within the livestock industry. In this review we discuss advances that have been made for the development and more effective utilization of kinome arrays for livestock species. Recent examples of the application of these approaches to a variety of priority livestock species (cattle, pigs, and chickens) in a number of different biological contexts (infectious disease and food quality) are presented. While the application of kinome arrays for livestock species is currently centralized to a handful of labs the increasing ease of development and application of these arrays, as well as the significance of emerging information, should prompt other livestock research groups to adopt this approach.