Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: March 14, 2011
Publication Date: N/A
Technical Abstract: The hypothesis underlying this project is that genome-wide information on genetic variation will increase accuracy of predictions of genetic merit; will enhance heritability and reliability of these predictions through improved pedigree information; and will improve detection of most quantitative trait loci underlying a trait when analyzed using linkage disequilibrium mapping. Therefore, the central aim of this project is to develop genomic tools to aid characterization of the structure and function of both the bovine and water buffalo genomes, and then apply these tools using novel statistical methodology to accelerate genetic improvement for traits of economic importance in both species. These goals will be accomplished through completion of the following objectives, by which these researchers expect to deliver genomic tools and knowledge that will accelerate production while maintaining desirable traits for heat and disease tolerance, thus enhancing the way the Pakistani dairy industry practices selection for genetic improvement: -Generation of a map of shared genetic variation between US and Pakistani dairy breeds and water buffalo based on 50,000 SNP marker genotypes. -Partial genome sequencing of Sahiwal and Dhanni cattle and whole genome sequencing of Nili-Ravi buffalos to generate additional SNP resources for genotyping. -Development of SNP assays and statistical analyses for whole genome association and whole genome selection studies of Pakistani animals.