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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Infectious Bacterial Diseases Research » Research » Publications at this Location » Publication #257101

Title: Brucellosis

Author
item Olsen, Steven
item GARIN-BASTUJI, B - French Food And Safety Agency(AFSSA)
item BLASCO, J - Center For Agri-Food Technology (CITA)
item NICOLA, A - National Board Of Animal Health (DILAB-SENSA)
item SAMARTINO, L - National Institute Of Agricultural Technology(INTA)

Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 5/30/2011
Publication Date: 1/31/2012
Citation: Olsen, S.C., Garin-Bastuji, B., Blasco, J.M., Nicola, A.M., Samartino, L. 2012. Brucellosis. In: Zimmerman, J.J., Karriker, L.A., Ramirez, A., Schwartz, K.J., Stevenson, G.W., editors. Diseases of Swine. 10th edition. Hoboken, N.J.: Wiley-Blackwell. p. 697-708.

Interpretive Summary: Brucella suisis an intracellular pathogen that causes reproductive losses in swine and zoonotic infections in people. Although an eradication program based on serologic detection and whole-herd depopulation has nearly eradicated the disease in the United States, it is endemic in feral swine. The bacteria is a significant human pathogen and is a significant cause of reported cases of human brucellosis in the U.S. Other countries around the world are also struggling with the economic costs associated with human infection or from being endemic in domestic livestock. This review discusses the epidemiology, lesions, immunity, and prevention and control of Brucella suis. Like other Brucella, this species use multiple molecular mechanisms to modify their environment in host cells and facilitate survival and replication and immunologic protection is via cell-mediated immunity. Regulatory programs are the most cost-efficient way to control Brucella suis and prevent human infection.

Technical Abstract: Brucella suisis an intracellular pathogen that causes reproductive losses in swine and zoonotic infections in people. Althought an eradication program based on serologic detection and whole-herd depopulation has nearly eradicated the disease in the United States, it is endemic in feral swine. The bacteria is a significant human pathogen and is a significant cause of reported cases of human brucellosis in the U.S. Other countries around the world are also struggling with the economic costs associated with human infection or from being endemic in domestic livestock. This review discusses the epidemiology, lesions, immunity, and prevention and control of Brucella suis. Like other Brucella, this species use multiple molecular mechanisms to modify their environment in host cells and facilitate survival and replication and immunologic protection is via cell-mediated immunity. Regulatory programs are the most cost-efficient way to control Brucella suis and prevent human infection.