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Title: VACCINATION WITH ALPHAVIRUS-DERIVED NEURAMINIDASE PARTIALLY PROTECTS CHICKENS AGAINST AVIAN INFLUENZA CHALLENGE

Author
item Sylte, Matthew
item ELLIS, W - ALPHAVAX, INC - N.C.
item HUBBY, B - ALPHAVAX, INC - N.C.
item Suarez, David

Submitted to: American Association of Avian Pathologists
Publication Type: Abstract Only
Publication Acceptance Date: 1/18/2006
Publication Date: 7/16/2006
Citation: Sylte, M.J., Ellis, W., Hubby, B., Suarez, D.L. 2006. Vaccination with alphavirus-derived neuraminidase partially protects chickens against avian influenza challenge [abstract]. American Association of Avian Pathologists. CD p. 97.

Interpretive Summary:

Technical Abstract: Antibodies produced against the influenza hemagglutinin protein protect against avian influenza (AI) infection, whereas the role of anti-neuraminidase (NA) antibodies is less clear. We hypothesized that primary response to NA vaccination was important in protection. Using chickens, we compared three different types of vaccines; either NA 2 (N2) replication deficient viral-like particles (VLP), baculovirus-derived protein or DNA vaccines, alone or in combination. Chickens vaccinated with VLP were partially protected against AI challenge, whereas other primary vaccination types failed to protect (e.g., DNA and baculovirus-derived). Results of NA-inhibition titers and AI shedding will be discussed. These results suggest that the VLP are more effective than DNA or baculovirus-derived NA in priming protective immunity against AI challenge.