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Title: CELL SIZE REGULATES HORMONE RELEASE IN THE OSMORECEPTIVE PROLACTIN CELL OF THE EURYHALINE TILAPIA, OREOCHROMIS MOSSAMBICUS

Author
item SEALE, ANDRE - UNIVERSITY OF HAWAII
item Weber, Gregory - Greg
item RICHMAN, NURNEY - UNIVERSITY OF HAWAII
item STETSON, MILTON - UNIVERSITY OF DELAWARE
item HIRANO, TETSUVA - UNIVERSITY OF HAWAII
item GRAU, E - UNIVERSITY OF HAWAII

Submitted to: Trends in Comparative Endocrinology
Publication Type: Proceedings
Publication Acceptance Date: 2/15/2004
Publication Date: 3/26/2004
Citation: Seale, A.P., Weber, G.M., Richman, N.H., Stetson, M.H., Hirano, T., Grau, E.G. 2004. Cell size regulates hormone release in the osmoreceptive prolactin cell of the euryhaline tilapia, oreochromis mossambicus. Trends in Comparative Endocrinology.

Interpretive Summary:

Technical Abstract: The release of prolactin (PRL), a freshwater osmoregulatory hormone in teleost fish, rises in vitro within 5 min after extracellular osmolality falls. An increase in cell size precedes this rise. Cell size and PRL release also increase, albeit more slowly, after the partial replacement of medium NaCl with an equivalent concentration of urea, a membrane-permeant molecule. Similar replacement using mannitol, which is membrane-impermeant, elicits no response. These findings suggest that osmoreception is linked to changes in cell volume rather than to extracellular osmolality per se.