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Title: INTESTINAL LYSINE METABOLISM IS DRIVEN BY THE ENTERAL AVAILABILITY OF DIETARY LYSINE IN PIGLETS FED A BOLUS MEAL

Author
item STOLL, BARBARA - BAYLOR COLL OF MEDICINE
item BOS, CECILE - INRA, FRANCE
item FOUILLET, HELENE - INRA, FRANCE
item GAUDICHON, CLAIRE - INRA, FRANCE
item GUAN, XINFU - BAYLOR COLL OF MEDICINE
item Grusak, Michael
item REEDS, PETER - BAYLOR COLL OF MEDICINE
item TOME, DANIEL - INRA, FRANCE
item Burrin, Douglas - Doug

Submitted to: Nutrition Conference Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 5/14/2003
Publication Date: 5/14/2003
Citation: STOLL, B., BOS, C., FOUILLET, H., GAUDICHON, C., GUAN, X., GRUSAK, M.A., REEDS, P.J., TOME, D., BURRIN, D.G. INTESTINAL LYSINE METABOLISM IS DRIVEN BY THE ENTERAL AVAILABILITY OF DIETARY LYSINE IN PIGLETS FED A BOLUS MEAL. NUTRITION CONFERENCE PROCEEDINGS. 9th International Symposium on Digestive Physiology in Pigs, Banff, AB, Canada. 2003. v. II. p. 10-18.

Interpretive Summary: Interpretive Summary not needed for this 115.

Technical Abstract: Studies in young pigs have shown that under conditions of continuous enteral feeding, the portal drain viscera (PDV) almost exclusively utilize arterial lysine. Since the mode of feeding might alter amino acid utilization kinetics, the aim of the present work was to quantify the postprandial kinetics of dietary and systemic lysine by the PDV and whole body after the ingestion of a large bolus meal. We found preferential first-pass use of dietary rather than arterial lysine during bolus feeding. We conclude that PDV lysine utilization shifts from the arterial to the enteral source as an increased dietary supply becomes available.