Submitted to: Virus Research
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: August 1, 2003
Publication Date: January 1, 2003
Citation: MASON, P.W., GRUBMAN, M.J., BAXT, B. MOLECULAR BASIS OF PATHOGENESIS OF FMDV. VIRUS RESEARCH.V 91:9-32, 2003 Interpretive Summary: Book Chapter
Technical Abstract: Foot-and-mouth disease virus (FMDV) is the prototype member of the Aphthovirus genus of the family Picornaviridae. The virus exists in the form of seven different serotypes: A, O, C, Asia1, and South African Territories 1 (SAT1), SAT2, and SAT3, but a large number of subtypes have evolved within each serotype. Work on the molecular biology of FMDV has provided key insights into the molecular basis of viral-induced disease. These include contributions into the nature of virulence factors such as the Lpro/IRES which appears to allow FMDV to circumvent its host's innate immune response. Host range of FMDV, a noted property of this pathogen, appears to be regulated by 3A, a replication complex-associated protein, through an as-of-yet unknown mechanism. In addition, FMDV receptor choice and utilization, and capsid stability, appear to target the virus to the tissues that are optimal for virus replication and development of disease. Further understanding of the basis of pathogenesis of FMD and other diseases will require in-depth studies of virus/host interactions at the subcellular and whole-animal levels.