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Title: BOVINE ADENOVIRUS SEROTYPE 10: ISOLATION CHARACTERIZATION AND EXPERIMENTAL INFECTION IN CALVES

Author
item Lehmkuhl, Howard
item Cutlip, Randall
item DEBEY, BRAD

Submitted to: Research Workers in Animal Diseases Conference Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: 9/28/1998
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Adenoviruses have been isolated from cattle in conjunction with respiratory tract disease and enteritis or both. Ten serotypes of bovine adenovirus (BAdV) are currently recognized by the International Committee on Taxonomy of Viruses. Of the ten serotypes, BAdV 1-4, and 7 have been isolated from cattle in the United States. A virus isolated from the lung, liver, kidney yand small intestine of a 3-month old Holstein heifer with a clinical history of pneumonia and lesions in multiple organs was identified as an adenovirus based on morphological and physicochemical characteristics. The objectives of this study were to serotype the virus and determine the pathogenic potential in calves. The adenovirus was determined to be a serotype 10 BAdV and represents the first reported isolation of this serotype in the United States. Inoculation of calves with this isolate resulted in mild to moderate clinical response. Gross lesions were minimal lin the respiratory tract and consisted of fibrin in the airways and small areas of consolidation in the cranial lobes of the lung. Mucofibrinous foci were present on the mucosa of the upper small intestine.