|Rimler, Richard - Rick|
Submitted to: Meeting Abstract
Publication Type: Proceedings
Publication Acceptance Date: 6/15/1998
Publication Date: N/A
Citation: Interpretive Summary:
Technical Abstract: This study evaluated the capacity of lipopolysaccharide (LPS) purified from Pasteurella multocida and/or gamma-irradiated non-viable Aspergillus fumigatus conidia (Af) to produce pathology when administered via the intra-air sac route in turkeys. Necropsies were performed at 1, 6, and 24 hr post-injection (PI). Macroscopic lesions were restricted to the ipsilateral lung and air sac. Acute lesions in the posterior thoracic air sac (PTAS) membrane were assessed by transmission electron microscopy. LPS generated severe suppurative airsacculitis with edema and epithelial cell detachment. Af injection produced epithelial degeneration and mesenchymal cell degeneration and necrosis. LPS + Af induced exudative airsacculitis with severe edema and necrosis. The results indicate that inhalation exposure to LPS and non-viable fungal elements may damage the air sac mucosal barrier, thereby increasing susceptibility to infectious airsacculitis. This study presents a model of aseptic airsacculitis in turkeys with probable clinical relevance.