Submitted to: American Society of Pharmacognosy
Publication Type: Abstract Only
Publication Acceptance Date: 7/24/1998
Publication Date: N/A
Technical Abstract: High moisture corn samples from Wisconsin suspected of causing dairy cattle problems (refusal to eat, bloating and diarrhea) were examined for toxigenic fungi. Fusarium moniliforme and F. proliferatum were the predominant species present in the samples and were assessed for their ability to produce mycotoxins on rice. A total of 26 Fusarium isolates were analyzed for moniliformin (MON) and for fumonisins B1 (FB1) and B2 (FB2). In addition, a new Fusarium metabolite of molecular composition C21H38N2O6 was produced by 7 of 12 F. proliferatum isolates and by 10 of 14 isolates of F. moniliforme. The tentative structure for the metabolite based on 1H, 13C NMR, and high resolution FAB/MS will be presented. This alpha-amino acid is toxic to duckweed at about the same magnitude as we reported for moniliformin (Vesonder et al., Mycopathologia 118:185-189, 1992).