Author
Andersen, Arthur | |
ROGERS, DOUGLAS - UNIV. OF NE, LINCOLN, NE |
Submitted to: Human Chlamydial Infection International Symposium Proceedings
Publication Type: Proceedings Publication Acceptance Date: 3/2/1998 Publication Date: N/A Citation: N/A Interpretive Summary: Technical Abstract: Chlamydia trachomatis strains are normally sensitive both to sulfadiazine and to tetracycline. While speciating chlamydial isolates from swine, we found that a number of swine isolates were highly resistant to sulfadiazine. In addition, the manager of one of the sampled herds had reported that tetracycline had only a limited and transient effect upon the chlamydial disease in the herd. Because of this, it was of interest to determine how wide-spread the resistance was to sulfadiazine and to tetracycline. Eight recently- isolated swine strains, along with a swine strain from Austria, were compared with a number of C. psittaci and C. trachomatis isolates for resistance to tetracycline and sulfadiazine. Six out of eight of the recently isolated swine C. trachomatis isolates were highly resistant to sulfadiazine. The remaining two recently isolated swine strains, the swine strain from the 1960s and the C. trachomatis strain were all sensitive. All of the recently isolated swine strains were resistant to tetracycline; whereas, the swine isolate from the 1960s and the other chlamydial isolates were all sensitive. The results show that a number of swine C. trachomatis strains are highly resistant to tetracycline and sulfadiazine. The resistance was likely acquired while these drugs were used as feed additives and is quite stable. Two tetracycline resistant strains were not resistant to sulfadiazine, indicating that the drug resistance is due to different mechanisms. |