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United States Department of Agriculture

Agricultural Research Service

Title: INVASIVE PULMONARY DISEASE CAUSED BY NEOSARTORYA PSEUDOFISCHERI, ASPERGILLUS NIGER, AND ASPERGILLUS FUMIGATUS)

Author
item Kammeyer, P
item Peterson, Stephen - Steve
item Stiff, P
item Yong, S
item Husain, A
item O'keefe, J
item Carey, R
item Bayer, R
item Kharzo, M
item Yeldandi, V

Submitted to: American Society for Microbiology
Publication Type: Abstract Only
Publication Acceptance Date: 5/21/1998
Publication Date: N/A
Citation:

Interpretive Summary:

Technical Abstract: A 27-year-old man underwent allogenic bone marrow transplant for chronic myelogenous leukemia. Four months after the procedure, the patent was admitted for treatment of pneumonia. Sputum cultures revealed Aspergillus niger and A. fumigatus. Amphotericin B lipid complex, itraconazole and sargramostim treatments were initiated. Two weeks later, bronchoscopic brush biopsy cultures revealed the presence of Aspergillus niger, A. fumigatus and Neosartorya pseudofischeri, suggesting invasive growth of fungi in lung tissue. N. pseudofischeri is rarely reported from human infections, and initially may resemble A. fumigatus, but is distinguished by ascocarp growth on culture plates. Its identity must be confirmed by scanning electron microscopy of the ascospore ornamentation which is unique and species-specific, or by sequencing of the internal transcribed spacer regions of the ribosomal DNA. Sequences of this and the ex type strain of N. pseudofischeri are in GenBank.

Last Modified: 8/24/2016
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