|Peterson, Stephen - Steve|
Submitted to: American Society for Microbiology
Publication Type: Abstract only
Publication Acceptance Date: 5/21/1998
Publication Date: N/A
Citation: Interpretive Summary:
Technical Abstract: A 27-year-old man underwent allogenic bone marrow transplant for chronic myelogenous leukemia. Four months after the procedure, the patent was admitted for treatment of pneumonia. Sputum cultures revealed Aspergillus niger and A. fumigatus. Amphotericin B lipid complex, itraconazole and sargramostim treatments were initiated. Two weeks later, bronchoscopic brush biopsy cultures revealed the presence of Aspergillus niger, A. fumigatus and Neosartorya pseudofischeri, suggesting invasive growth of fungi in lung tissue. N. pseudofischeri is rarely reported from human infections, and initially may resemble A. fumigatus, but is distinguished by ascocarp growth on culture plates. Its identity must be confirmed by scanning electron microscopy of the ascospore ornamentation which is unique and species-specific, or by sequencing of the internal transcribed spacer regions of the ribosomal DNA. Sequences of this and the ex type strain of N. pseudofischeri are in GenBank.