Submitted to: United States Japan Seminar Series
Publication Type: Abstract only
Publication Acceptance Date: 12/9/1997
Publication Date: N/A
Citation: Interpretive Summary:
Technical Abstract: A three-month old Holstein heifer (T93-1621) was submitted to the Tulare Branch of the California Veterinary Diagnostic Laboratory System for necropsy. There was consolidation of approximately 15% of the left anterior lung lobe. The affected area was plum colored and slightly collapsed. The remaining lung was grossly normal. The lumen of the spiral lcolon contained long strands of fibrin and there were multifocally extensive eroded areas in the spiral colon. Microscopic lesions consisted of suppurative bronchiolitis and bronchopneumonia. Basophilic inclusions, either partially or totally filling nuclei, were present within endothelial cells of capillaries of the interstitium of the kidney, within bronchiolar epithelial cells and interstitial capillary endothelial cells of the lung, and within capillary endothelial cells in the lamina propria of the mucosa of the intestinal tract. Virus was isolated from the lung, liver, kidney and small intestine and identified as an adenovirus based on morphological and physicochemical characteristics.The viral isolate was determined to be a serotype 10 bovine adenovirus and represents the first reported isolation of this serotype in the United States. Inoculation of calves with this isolate resulted in mild to moderate clinical response. Gross lesions were minimal in the respiratory tract and consisted of fibrin in the airways and small areas of consolidation in the cranial lobes of the lung. Mucofibrinous foci were present on the mucosa of the upper small intestine.