Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 12/1/1997
Publication Date: N/A
Citation: Interpretive Summary: Interpretive Summary not needed for this 115.
Technical Abstract: Mammary-specific overexpression of des(1-3) hIGF-I in transgenic mice results in increased frequency of mammary hyperplasia and adenocarcinoma. The growth of these hyperplasias appears to be associated with abnormally constitutive expression of the transgene. Overexpression of des(1-3)hIGF-I inhibits apoptosis during late lactation by an as-yet-undefined mechanism. Studies from other systems suggest that this mechanism involves early events such as activation of Akt/PKB, phosphorylation of BAD and inhibition of jun kinase, and delayed events such as increased expression of bcl-x. The definition of this mechanism within mammary cells is the goal of future studies.