Submitted to: Federation of American Societies for Experimental Biology Conference
Publication Type: Abstract Only
Publication Acceptance Date: 4/3/1998
Publication Date: N/A
Technical Abstract: Studies with rats have found that an interaction between fructose and magnesium (Mg) affects macromineral metabolism; high dietary fructose significantly increased kidney calcification in both male and female rats, particularly when dietary Mg was low (Magnesium Res 4:97, 1991). To evaluate this interaction in humans, eleven men aged 22-40 y were fed a mixed Western diet for four 42 d diet periods in which dietary Mg was either approximately 170 or 370 mg/d, and dietary fructose was either 4 or 19% of energy. A decaffeinated beverage containing high fructose corn syrup replaced cornstarch, bread and rice in the low fructose diet to give the high fructose diet. High dietary fructose significantly (P<0.01) increased Mg balance, during both low and high dietary Mg intakes. Ultrafilterable and ionized serum magnesium also apparently were related to Mg and fructose intakes; they were higher when fructose was fed and when Mg intakes were high. High fructose depressed Ca balance: the effect tended to be more marked when dietary Mg was low. High dietary fructose also significantly (P<0.005) decreased phosphorous (P) balance. Urinary P losses were significantly (P<0.001) higher when high dietary fructose was fed. High dietary fructose also increased the concentration of serum alkaline phosphatase (P<0.005). These findings indicate that dietary fructose adversely affects macromineral metabolism in humans and suggests further studies to see if a high fructose diet coupled with low dietary Mg and marginal Ca leads to bone loss.