Submitted to: Animal Genetics
Publication Type: Abstract Only
Publication Acceptance Date: 9/11/1997
Publication Date: N/A
Technical Abstract: Myostatin belongs to the transforming growth factor-beta superfamily and is expressed specifically in developing and mature skeletal muscle. Myostatin appears to act as a negative regulator of muscle development, since mice with targeted disruption of this gene display a large increase in muscle mass. The porcine myostatin gene was determined to lie at chromosome 15q2.3 by fluorescence in situ hybridization. Myostatin was also positioned within the chromosome 15 linkage group using both a polymorphism located in the second intron and an associated microsatellite. The development of highly polymorphic markers associated with myostatin will support population studies to identify alleles of this gene affecting muscle mass and/or fat deposition in swine.