Submitted to: International Virtual Conference on Infectious Diseases of Animals
Publication Type: Abstract Only
Publication Acceptance Date: 8/12/1998
Publication Date: N/A
Citation: N/A Interpretive Summary:
Technical Abstract: The Second International Swine Cluster of Differentiation (CD) Workshop was organized to standardize the assignment of monoclonal antibody (mAb) reactivity to swine leukocyte antigens. This workshop was supported by the Veterinary Immunology Committee (VIC) of the IUIS and was chaired by Armin Saalm¿ller. A total of 176 mAb and 9 standard mAb were analyzed. Analyses performed with the whole panel of mAb led to 22 preliminary clusters. MAb were then distributed to different subset groups for more detailed clustering and epitope analyses. As a result of the summary workshop session, revisions were made in the nomenclature for Swine CD: Swine CD# are assigned to swine orthologues of human CD based on tissue distribution, appropriate molecular mass of the antigen, and sequence of the respective molecule. Workshop CD# (wCD#) are assigned when there is not yet appropriate sequence for the swine antigen. Swine workshop cluster # (SWC#) are assigned for clusters of 2 or more mAb with common phenotypes on swine cells. Based on this revised nomenclature the following CDs [and new assignments of mAb from this second workshop] are designated in swine: wCD1, CD2 [2 new mAb], CD3 , CD4 , CD5 , CD6 , CD8 [1 mAb against the CD8a epitope, 2mAb against a new CD8c epitope], wCD11, CD14 , CD16 , wCD21 , wCD25 , wCD29 , CD44, wCD45 , wSWC1  and SWC7 . Two new clusters each were characterized in the workshop. These internationally characterized mAb should be very useful for scientists using the pig for biomedical research.