Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 5/7/1997
Publication Date: N/A
Interpretive Summary: This chapter reviews natural products that inhibit oogenesis in a variety of insects and a describes their modes of action. Some oostatins prevent yolk protein uptake while others inhibit digestion of a protein meal or prevent yolk protein synthesis. Oostatins are responsible for the cyclical production of eggs and have a potential as novel insect control agents.
Technical Abstract: Oostatins, folliculostatins, and antigonadotropins are naturally occurring materials that inhibit vitellogenic development in oocytes. The apparent role of oostatins is to regulate egg development cycles. When eggs are produced in cycles, only the ultimate cycle develops and oogenesis in the penultimate cycle is arrested. Insects inhibit oogenesis through two different pathways. In several species, the oostatin inhibits follicle cell patency, while in others, vitellogenin production is inhibited. Thus far, five unique peptides with oostatic activity have been identified. Oostatins found in different species may be produced by the ovaries, abdominal neurosecretory organs, or the central nervous system.