|Knowles Jr, Donald|
Submitted to: Infection and Immunity
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/6/1996
Publication Date: N/A
Interpretive Summary: Eventual control of anaplasmosis in the United States will require a safe and efficacious vaccine. Prior to development of a safe and efficacious vaccine, the mechanisms by which cattle control anaplasmosis must be determined. This work shows that blood cells from infected cattle produce a factor(s) that are able to kill Anaplasma marginale in vitro. Further work will be necessary to characterize this factor(s) and determine how to stimulate its production through vaccination.
Technical Abstract: Blood mononuclear cells (lymphocytes and monocytes) were isolated from infected calves during in vivo control of acute anaplasmosis and cultured with Anaplasma marginale organisms. Supernatants from the cultures reduced the proportion of erythrocytes containing viable A. marginlae in vitro, indicating that an antibody-independent mechanism of rickettsemia control might occur during acute anaplasmosis.