Submitted to: Animal Genetics
Publication Type: Abstract Only
Publication Acceptance Date: 8/26/1997
Publication Date: N/A
Citation: Interpretive Summary:
Technical Abstract: Linkage maps based on over 1,000 microsatellite markers have been developed for pigs and cattle. A well defined comparative map between human and livestock species will compliment the genetic maps and facilitate development of markers for positional candidate genes to identify the genes responsible for genetic variation in quantitative traits for livestock. Chromosomal segments with conserved synteny between human and swine have been broadly defined using heterologous chromosomal painting and refined with bidirectional chromosomal painting. An additional resource for studying conserved syntenic groups in pigs is the well characterized somatic cell hybrid panel developed by Yerle et al. (1996). However, these procedures are unable to determine the extent of conservation in gene order. Preliminary comparative mapping results reported by Johansson et al. (1995) relied on only a few comparative loci per chromosome. Thus, we initiated a project to link coding sequences in the porcine genetic map to study the extent of conservation of gene order between man and pigs. Improvements in the comparative map will ultimately be useful to identify genes with significant effects on economically important traits in pigs. Our initial efforts yielded the first comparative linkage map for any livestock species on the X chromosome. Here we report mapping genes located on HSA2 and 12 to porcine chromosomes (SSC) 15 and 5, respectively.