|Nielsen, Forrest - Frosty|
|Poellot, Rhonda Lee|
Submitted to: Federation of American Societies for Experimental Biology Conference
Publication Type: Abstract Only
Publication Acceptance Date: 4/6/1997
Publication Date: N/A
Technical Abstract: The diabetes-prone (DP) BB rat is model for type l diabetes mellitus and lymphocytic thyroiditis. The thyroiditis is exacerbated by high dietary iodine (I). Vanadium (V) affects diabetes and the response to dietary I. Thus, to ascertain whether the BB rat is a sensitive model to use for the study of V nutrition, male weanling BB/Wor rats were assigned to groups of f 8 in a 3-way 2 x 2 x 2 factorially arranged experiment. Diabetes- resistant (DR) and DP rats were fed an acid-washed ground corn and casein based diet (containing about 50 ng I and 2 ng V/g) supplemented with V at 0 (-V) or 0.5 (+V) ug/g and I at 0 (-I) and 25 (+I) ug/g. The rats were fed ad lib their respective diets for 90 days. Only one (+I) of the 16 -V DP rats developed diabetes, whereas four (one -I, and three +I) of the 16 +V DP rats developed diabetes; these rats were not included in the following comparisons. Plasma T4 concentrations were lower and T3 concentrations were higher in +V than -V rats fed -I; +I changed the +V values such that they were not different than the -V values, which were not markedly affected by dietary I. Pancreatic amylase activity was lower in +V than -V rats, and was decreased by +I in +V DP rats and -V DR rats; amylase was not affected by dietary I in the +V DR rats or -V DP rats. Serum lactate dehydrogenase activity was increased in +V rats fed +I, but decreased in -V rats fed +I. The findings indicate that the BB rat is an excellent model for the study of the nutritional importance of V, which apparently involves thyroid and glucose metabolism.