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ARS Home » Research » Publications at this Location » Publication #75619
Title: PHAGOCYTIC AND OXIDATIVE ACTIVITIES OF BOVINE NEUTROPHILS AFTER PRIMING BY TNF-A ANC C5A DESARG

Author
item RAINARD, P - INRA
item Paape, Max
item POUTREL, B - INRA

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 12/5/1996
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Neutrophils can be primed by inflammatory mediators to have enhanced functional activity, so that when they reach the site of an infection, these cells are no longer in a quiescent state as they are in the blood compartment, but are ready to exert their phagocytic and bactericidal potential. Here we show that bovine recombinant TNF-a and purified C5a desArg, inflammatory agents commonly encountered at infection sites, were able to enhance the in vitro phagocytosis of Staphylococcus aureus by bovine neutrophils, and that the most efficient phagocytosis was obtained when the cytokine and the chemoattractant acted together.