Submitted to: Institute for International Cooperation in Animal Biologics
Publication Type: Proceedings
Publication Acceptance Date: 6/3/1996
Publication Date: N/A
Citation: Interpretive Summary:
Technical Abstract: Atrophic rhinitis and pneumonia in swine due to infection with Bordetella bronchiseptica and/or Pasteurella multocida remains a widespread and costly problem for producers. The severity of the disease varies greatly and is dependent on a number of factors including etiology, management practices, age, genetic background, and air and environmental quality. Diagnosis of infection is frequently problematic, but newly developed nucleic acid-base assays may permit more reliable and rapid identification of both P. multocida and B. bronchiseptica. A dermonecrotic toxin made by P. multocida is primarily responsible for the effects of this organism in swine. Vaccines containing inactivated toxin are effective in the reduction of disease but do not prevent infection. The toxins and other virulence factors of B. bronchiseptica that are important in the pathogenesis of disease have not been definitively elucidated. Although some bacterin-based vaccines for this organism are currently available, their efficacy is not high. Development of improved vaccines that will prevent both disease and infection due to P. multocida and B. bronchiseptica will depend on a more complete understanding of the function and regulation of virulence factors of both organisms.