Submitted to: Book Chapter
Publication Type: Abstract Only
Publication Acceptance Date: 5/31/1996
Publication Date: N/A
Technical Abstract: A collaborative mapping effort between the USDA, ARS, Roman L. Hruska US Meat Animal Research Center (MARC) and the University of Minnesota was established to integrate physical and genetic linkage maps of the pig and map loci associated with disease resistance, growth and development, and carcass traits. These efforts are supported by construction of a microsatellite linkage map of the pig using exotic Chinese germplasm crossed to conventional US breeding stock (MARC and the University of Illinois). It is expected that the maps will aid in the identification of genetic markers which can be incorporated into a marker-assisted selection breeding programme. Allelic frequencies for framework microsatellites in commercial breeds have also been determined. The first swine chromosome workshop devoted to a single chromosome developed a framework and comprehensive map of chromosome 6, and led to the organization of a workshop focused on swine chromosome 7, set for later this year. Physical mapping efforts are centred on assigning cosmid and lambda genomic clones containing informative microsatellites using fluorescent in situ hybridization (FISH). We are selecting a set of framework markers (based on heterozygosity, quality of amplified product and physical location) which can be incorporated into automated flourescent genotyping protocols useful for QTL mapping in most swine resource populations.