Submitted to: American Journal of Veterinary Research
Publication Type: Peer reviewed journal
Publication Acceptance Date: 5/27/1996
Publication Date: N/A
Citation: Interpretive Summary: Mycotoxins are poisons produced by molds that can cause disease or death in humans and animals. They can cause serious economic losses in the livestock industry. In this study, two fairly common mycotoxins were fed in combination to growing pigs. The combination produced disease that was much worse than either poison alone. Awareness of this could help prevent serious disease problems in the swine industry, thus potentially saving vast sums of money.
Technical Abstract: The effect of fumonisin B1 (FB1)-contaminated diets (from Fusarium moniliforme culture material) and deoxynivalenol (DON)-contaminated (from naturally contaminated wheat) diets, fed singly and in combination to growing barrows were evaluated. Six barrows (3 replicates of 2 each, mean body weight, 13.6 kg) per group were fed: 0 mg of FB1, 0 mg of DON/kg of feed (control); 100 mg of FB1/kg of feed; 5 mg of DON/kg of feed; or 100 mg of FB1 plus 5 mg of DON/kg of feed for 28 days. The toxins in combination significantly (P<0.01) decreased body weight and body weight gain in a synergistic fashion. Serum biochemical analytes and immune response were affected by FB1 and by the FB1 plus DON treatments. The most consistent pathologic observations were hepatic necrosis, renal nephrosis, and hypertrophy of pulmonary arteries in tissues of barrows fed FB1 diets, and hepatic necrosis and renal nephrosis in tissues of barrows fed diets containing FB1 and DON. For the parameters we evaluated, measurements were affected more by the combination of these two Fusarium toxins than either toxin alone and the interactions could be described as additive and frequently were synergistic.