Submitted to: International Symposium on Selenium in Biology and Medicine
Publication Type: Abstract Only
Publication Acceptance Date: 8/19/1996
Publication Date: N/A
Citation: N/A Interpretive Summary:
Technical Abstract: Selenium (Se) intake has been related to mood in several studies, but none examined mood states of populations with low Se intakes and status. The present study was designed to determine whether moderate Se supplementation might have beneficial consequences for mood in such individuals. Thirty-three females and 18 males from Dunedin, NZ were randomly assigned to 1 of 5 treatment groups to receive either 0, 10, 20, 30 or 40 ug Se/d, as selenomethionine, for approximately 6 months. Supplements were dispensed weekly and subjects were blinded to treatment. Prior to supplementation and again once each month, subjects completed the Profile of Mood States, Bi-Polar Form (POMS-BI), which measures mood on 6 specific scales, Agreeable-Hostile, Clearheaded-Confused, Composed- Anxious, Confident-Unsure, Elated-Depressed, and Energetic-Tired, plus a derived measure, Total Mood Disturbance (TMD). Slopes from the regression of treatment on month in study (i.e., duration of treatment) were contrasted between treatment groups and compared to zero (no change over time with treatment). For females, there were differences between groups on the Agreeable-Hostile (p=0.047), Confident-Unsure (p=0.040) and Energetic-Tired (p=0.017) scales of the POMS-BI. For all 3 scales, the group receiving 40 ug Se/d showed significant (p<0.05) improvement in mood over the course of the study; for Confident-Unsure, the group receiving 30 ug Se/d also improved (p=0.030). Slopes for TMD were different among treatment groups (p=0.036); the group receiving 40 ug Se/d reported less (P=0.006) TMD as the study progressed. Findings are important because they indicate a functional consequence of low Se intakes and status in a population which exhibits no apparent Se-related health effects.