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Title: CHROMATOGRAPHY AND MULTICHANNEL DETECTION METHODS - CHAPTER 13

Author
item RUSLING, JAMES
item Kumosinski, Thomas

Submitted to: Nonlinear Computer Modeling of Chemical and Biochemical Data
Publication Type: Book / Chapter
Publication Acceptance Date: 5/4/1995
Publication Date: N/A
Citation: N/A

Interpretive Summary: Book chapter - interpretive summary is not required.

Technical Abstract: In chapter 13, specific examples of the use of nonlinear regression analysis to resolve signals in multicomponent analyses are presented. At first, resolution of chromatographic peaks with single-channel detection, including examples from high- pressure liquid chromatography and high performance size- exclusion chromatography are discussed. Following this, powerful and information-rich multichannel methods characteristic of chromatography coupled with detection by mass, infrared or UV-VIS detection are shown. Also included is a section on multicomponent time-resolved fluorescence, which is representative of any time resolved spectroscopic method. While this chapter could contain examples of many more techniques, it is important to stress the generality of the approach, that it can be applied to other similar types of methods.