Submitted to: Vaccine
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 1/1/1992
Publication Date: N/A
Citation: Interpretive Summary: Foot-and-mouth disease is controlled by vaccinating with virus which has been killed with a chemical called an imine. Because of the potential problem of handling large amounts of virus, other approaches which do not involve use of the infectious virus have been studied, based on the knowledge that only part of the virus is required to confer protection. Methods to produce these parts have been worked out and the products teste in experimental animals.
Technical Abstract: The economically important foot-and-mouth disease has been successfully controlled in Western Europe by comprehensive immunization using killed vaccine. The author discusses the wisdom of abandoning this policy, and outlines research into alternative vaccines using recombinant DNA technology, in particular using synthetic peptides.