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ARS Home » Pacific West Area » Albany, California » Western Regional Research Center » Produce Safety and Microbiology Research » Research » Publications at this Location » Publication #434241
Research Project: Rapid Antemortem Tests for the Early Detection of Transmissible Spongiform Encephalopathies and Other Animal Diseases

Location: Produce Safety and Microbiology Research

Title: Mapping the surface of a prion using mass spectrometry

Author
item Silva, Christopher

Submitted to: Journal of American Society for Mass Spectrometry
Publication Type: Other
Publication Acceptance Date: 4/23/2026
Publication Date: 7/1/2026
Citation: Silva, C.J. 2026. Mapping the surface of a prion using mass spectrometry. Journal of American Society for Mass Spectrometry. 37(7) Cover.

Interpretive Summary:

Technical Abstract: A MRM-based method can quantitate the oxidation of methionine-containing tryptic peptides, providing a means of measuring the surface exposure of methionines in prions after chemical oxidation.