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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Food Safety and Enteric Pathogens Research » Research » Publications at this Location » Publication #428473
Research Project: Intestinal Microbial Ecology and Non-Antibiotic Strategies to Limit Shiga Toxin-Producing Escherichia coli (STEC) and Antimicrobial Resistance Transmission in Food Animals

Location: Food Safety and Enteric Pathogens Research

Title: A pig with functional human immunity

Author
item TUGGLE, CHRISTOPHER - Iowa State University
item Loving, Crystal
item WEBBER, BEAU - University Of Minnesota

Submitted to: Nature Biomedical Engineering
Publication Type: Other
Publication Acceptance Date: 6/1/2025
Publication Date: 6/11/2025
Citation: Tuggle, C., Loving, C.L., Webber, B.R. 2025. A pig with functional human immunity. Nature Biomedical Engineering. https://doi.org/10.1038/s41551-025-01426-4.
DOI: https://doi.org/10.1038/s41551-025-01426-4

Interpretive Summary:

Technical Abstract: Genetically modified immunodeficient pigs support the development of functional human B and T cells and represent a preclinical model for investigating human haematopoiesis and a bioreactor for large-scale production of human immune cells for diverse therapies.