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ARS Home » Northeast Area » Ithaca, New York » Robert W. Holley Center for Agriculture & Health » Plant, Soil and Nutrition Research » Research » Publications at this Location » Publication #427995
Research Project: Genetic Regulation of Fruit and Vegetable Nutritional Quality and Maturation and Technology Development

Location: Plant, Soil and Nutrition Research

Title: ORANGE family proteins: multifunctional chaperones shaping plant carotenoid level, plastid development, stress tolerance, and more

Author
item WRIGHTSTONE, EMALEE - Cornell University
item XU, LILIN - Cornell University
item RAO, SOMBIR - Cornell University
item HAZRA, ABHIJIT - Cornell University
item Li, Li

Submitted to: Trade Journal Publication
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 4/11/2025
Publication Date: 5/9/2025
Citation: Wrightstone, E., Xu, L., Rao, S., Hazra, A., Li, L. 2025. ORANGE family proteins: multifunctional chaperones shaping plant carotenoid level, plastid development, stress tolerance, and more. Molecular Horticulture 5:43. https://doi.org/10.1186/s43897-025-00169-9.
DOI: https://doi.org/10.1186/s43897-025-00169-9

Interpretive Summary: A review paper

Technical Abstract: ORANGE (OR) family proteins are DnaJE1 molecular chaperones ubiquitous and highly conserved in all plant spe- cies, indicating their important roles in plant growth and development. OR proteins have been found to exert multiple functions in regulating carotenoid and chlorophyll biosynthesis, plastid development, and stress tolerance, with additional functions expected to be discovered. As molecular chaperones, OR proteins directly influence the sta- bility of their target proteins via their holdase activity and may perform other molecular roles through unknown mechanisms. Exploration of OR has uncovered novel mechanisms underlying core plant metabolism pathways and expanded our understanding of processes linked to plastid development. Continued investigation of OR fam- ily proteins will not only reveal new functions of molecular chaperones but also provide pioneering tools for crop improvement. Thus, OR family proteins offer a distinctive opportunity to comprehend molecular chaperones in modulating various metabolic and developmental processes and exemplify the importance of chaperones in crop development and adaptability. This review briefly details the history of OR family proteins, highlights recent advance- ments in understanding their myriad of functions, and discusses the prospects of this fascinating group of chaperones towards generating innovative, more nutritious, and resilient crops alongside other agronomically important traits.