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ARS Home » Plains Area » Houston, Texas » Children's Nutrition Research Center » Research » Publications at this Location » Publication #427030
Research Project: Regulatory Aspects of Obesity Development

Location: Children's Nutrition Research Center

Title: Perineuronal nets' role in metabolism

Author
item ZHANG, NAN - Huazhong University Of Science And Technology
item SONG, BEITE - Huazhong University Of Science And Technology
item BAI, PENG - Huazhong University Of Science And Technology
item DU, LI - Huazhong University Of Science And Technology
item CHEN, LULU - Huazhong University Of Science And Technology
item XU, YONG - Children'S Nutrition Research Center (CNRC)
item ZENG, TIANSHU - Huazhong University Of Science And Technology

Submitted to: American Journal of Physiology - Endocrinology and Metabolism
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/5/2024
Publication Date: 8/14/2024
Citation: Zhang, N., Song, B., Bai, P., Du, L., Chen, L., Xu, Y., Zeng, T. 2024. Perineuronal nets' role in metabolism. American Journal of Physiology - Endocrinology and Metabolism. 327:E411-E421. https://doi.org/10.1152/ajpendo.00154.2024.
DOI: https://doi.org/10.1152/ajpendo.00154.2024

Interpretive Summary: Perineuronal nets (PNNs) are specialized structures that surround nerve cells and play an important role in controlling metabolism. This review looks at recent research on how PNNs influence energy balance and blood sugar levels in the body. It also explores new discoveries about how factors like brain support cells (astroglia and microglia), sex hormones, nutrition, daily biological rhythms, and aging affect PNNs. These findings highlight the complex role PNNs play in maintaining metabolic health.

Technical Abstract: Perineuronal nets (PNNs), specialized extracellular matrix (ECM) structures that envelop neurons, have recently been recognized as key players in the regulation of metabolism. This review explores the growing body of knowledge concerning PNNs and their role in metabolic control, drawing insights from recent research and relevant studies. The pivotal role of PNNs in the context of energy balance and whole body blood glucose is examined. This review also highlights novel findings, including the effects of astroglia, microglia, sex and gonadal hormones, nutritional regulation, circadian rhythms, and age on PNNs dynamics. These findings illuminate the complex and multifaceted role of PNNs in metabolic health.