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Research Project: Viral Ecology of Henipaviruses in Endemic Settings and Intervention Strategies to Prevent their Spread to Domestic Animals

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Title: Presumed transmission of 2 distinct monkeypox virus variants from Central African Republic to Democratic Republic of the Congo

Author
item VAKANIAKI, EMMANUEL - Institute National Research Biomedical
item KINGANDA-LUSAMAKI, EDDY - Institute National Research Biomedical
item MERRITT, SYDNEY - University Of California (UCLA)
item KASONGO, FRANCOIS - Institute National Research Biomedical
item MALEMBI, EMILE - Ministry Of Public Health
item LUNYANGA, LYGIE - Institute National Research Biomedical
item LINSUKE, SYLVIE - Institute National Research Biomedical
item HALBROOK, MEGAN - University Of California (UCLA)
item KALTHAN, ERNEST - Ministry Of Health And Population
item PUKUTA, ELISABETH - Institute National Research Biomedical
item AZIZA, ADRIENNE - Institute National Research Biomedical
item CIGOLO, JEAN CLAUDE - Institute National Research Biomedical
item LUMEMBE, RAPHAEL - Institute National Research Biomedical
item KABAMBA, GABRIEL - Institute National Research Biomedical
item ANTA, YVON - Institute National Research Biomedical
item BOLUNZA, PIERROT - Provincial Health Division, South Ubangi
item KANDA, INNOCENT - Provincial Health Division, South Ubangi
item NGAZOBO, RAOUL - Provincial Health Division, South Ubangi
item KALONJI, THIERRY - Ministry Of Public Health
item NSIO, JUSTUS - Ministry Of Public Health
item MATOKA, PATRICIA - Ministry Of Public Health
item MWAMBA, DIEUDONNE - Ministry Of Public Health
item NGANDU, CHRISTIAN - Ministry Of Public Health
item SHAW, SOURADET - University Of Manitoba
item SHONGO, ROBERT - Ministry Of Public Health
item MADINGA, JOULE - Institute National Research Biomedical
item BOUM, YAP - Institut Pasteur De Bangui (IPB)
item LIESENBORGHS, LAURENS - Institute Of Tropical Medicine
item DELAPORTE, ERIC - University Of Montpellier
item AYOUBA, AHIDJO - University Of Montpellier
item LOW, NICOLA - University Of Bern
item MUNDEKE, STEVE - Ministry Of Public Health
item Hensley, Lisa
item TAMFUM, JEAN-JAQUES - Institute National Research Biomedical
item NAKOUNE, EMMANUEL - Institut Pasteur De Bangui (IPB)
item PEETERS, MARTINE - University Of Montpellier
item HOFF, NICOLE - University Of California (UCLA)
item KINDRACHUK, JASON - University Of Manitoba
item RIMOIN, ANNE - University Of California (UCLA)
item MBALA-KINGEBENI, PLACIDE - Institute National Research Biomedical

Submitted to: Emerging Infectious Diseases
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/19/2024
Publication Date: 8/29/2024
Citation: Vakaniaki, E.H., Kinganda-Lusamaki, E., Merritt, S., Kasongo, F., Malembi, E., Lunyanga, L., Linsuke, S., Halbrook, M., Kalthan, E., Pukuta, E., Aziza, A.A., Cigolo, J.M., Lumembe, R., Kabamba, G., Anta, Y., Bolunza, P., Kanda, I., Ngazobo, R., Kalonji, T., Nsio, J., Matoka, P., Mwamba, D., Ngandu, C., Shaw, S.Y., Shongo, R., Madinga, J., Boum, Y., Liesenborghs, L., Delaporte, E., Ayouba, A., Low, N., Mundeke, S.A., Hensley, L.E., Tamfum, J.M., Nakoune, E., Peeters, M., Hoff, N.A., Kindrachuk, J., Rimoin, A.W., Mbala-Kingebeni, P. 2024. Presumed transmission of 2 distinct monkeypox virus variants from Central African Republic to Democratic Republic of the Congo. Emerging Infectious Diseases. 30(10):2128-2134. https://doi.org/10.3201/eid3010.241118.
DOI: https://doi.org/10.3201/eid3010.241118

Interpretive Summary: Mpox is a re-emerging disease endemic to Central Africa - specifically the Democratic Republic of the Congo (DRC). In this paper, we describe linked mpox transmission across the international borders of DRC and neighboring Central African Republic. This documentation has greater implications for mpox and general disease surveillance.

Technical Abstract: We linked 4 mpox cases in South Ubangi, Democratic Republic of the Congo, to transboundary transmission from Central African Republic. Viral genome sequencing demonstrated that the monkeypox virus sequences belonged to distinct clusters of subclade Ia. This finding demonstrates the borderless nature of mpox and highlights the need for vigilant regional surveillance.