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ARS Home » Northeast Area » Beltsville, Maryland (BARC) » Beltsville Agricultural Research Center » Animal Genomics and Improvement Laboratory » Research » Publications at this Location » Publication #420438
Research Project: Accelerating Genetic Improvement of Ruminants Through Enhanced Genome Assembly, Annotation, and Selection

Location: Animal Genomics and Improvement Laboratory

Title: The Farm Animal Genotype-Tissue Expression (FarmGTEx) Portal

Author
item FANG, LINGZHAO - Aarhus University
item THE FARMGTEX, CONSORTIUM - Collaborator
item LI, JINGYI JESSICA - University Of California (UCLA)
item FRANTZ, LAURENT - Queen Mary University Of London
item ZHOU, HUAIJUN - University Of California
item ZHANG, ZHE - South China Agricultural University
item Liu, Ge

Submitted to: World Wide Web
Publication Type: Database / Dataset
Publication Acceptance Date: 2/6/2025
Publication Date: 3/17/2025
Citation: Fang, L., FarmGTEx Consortium, Li, J.J., Frantz, L., Zhou, H., Zhang, Z., Liu, G.E. 2025. The Farm Animal Genotype-Tissue Expression (FarmGTEx) Portal. Nature Genetics. 57(4):786-796. https://doi.org/10.1038/s41588-025-02121-5. Available: https://www.farmgtex.org/.
DOI: https://doi.org/10.1038/s41588-025-02121-5

Interpretive Summary: The Farm Animal Genotype-Tissue Expression (FarmGTEx) Consortium benefits internal and external stakeholders by providing open access to valuable results through this web portal. This resource is particularly useful for genomics research by prioritizing and interpreting existing GWAS signals and guiding genomic engineering by pinpointing tissue targets and developmental stages. Researchers, breeders, and policymakers can easily search for genes, cell types, tissues, variants, and traits, facilitating informed decision making.

Technical Abstract: The Farm Animal Genotype-Tissue Expression (FarmGTEx) Portal was built by the Animal Genomics and Improvement Laboratory in Beltsville, Maryland, and collaborators as the web portal (https://www.farmgtex.org/) for the FarmGTEx Consortium, an ongoing international collaborative endeavor. It aims to elucidate the genetic and evolutionary determinants of gene expression variation across terrestrial and aquatic domestic species under diverse biological contexts and environmental conditions. FarmGTEx will serve as a platform for fundamental discoveries of context-specific genetic control of gene expression, which will not only deepen our understanding of molecular and evolutionary mechanisms underlying complex phenotypic diversity within and between species, but also contribute to a sustainable agriculture-based food system, comparative biology, and human biomedicine.