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ARS Home » Southeast Area » Oxford, Mississippi » Natural Products Utilization Research » Research » Publications at this Location » Publication #420081
Research Project: Biobased Pesticide Discovery and Product Optimization and Enhancement from Medicinal and Aromatic Crops

Location: Natural Products Utilization Research

Title: Isoxazoline: An emerging scaffold in pesticide discovery

Author
item KONG, LING-JIE - Zhejiang University Of Technology
item CAO, XIN-YU - Zhejiang University Of Technology
item SUN, NA-BO - Zhejiang Shuren University
item MIN, LI-JING - Huzhou University
item DUKE, STEPHEN - University Of Mississippi
item WU, HONG-KE - Zhejiang University Of Technology
item ZHANG, LI-QIN - Huzhou University
item LIU, XING-HAI - Zhejiang University Of Technology

Submitted to: Journal of Agricultural and Food Chemistry
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 3/21/2025
Publication Date: 4/3/2025
Citation: Kong, L., Cao, X., Sun, N., Min, L., Duke, S.O., Wu, H., Zhang, L., Liu, X. 2025. Isoxazoline: An emerging scaffold in pesticide discovery. Journal of Agricultural and Food Chemistry. 2025(73):8678-8693. https://doi.org/10.1021/acs.jafc.4c09612.
DOI: https://doi.org/10.1021/acs.jafc.4c09612

Interpretive Summary: Heterocycles with nitrogen and oxygen atoms are important structural units in many pharmaceuticals or pesticides due to their extensive biological activities. Among them, isoxazoline, an important five-membered nitrogen and oxygen-containing heterocycle, has led to the discovery of many agrochemicals used for crop protection, such as herbicides, insecticides, and fungicides. Because of their important agricultural use, isoxazoline became a key fragment in pesticide discovery. Numerous marketed pesticides contain an isoxazoline motif as key skeleton. Hence, the exploration of isoxazoline derivatives remains an important research area in pesticide discovery. This review provides an up-to-date overview of isoxazoline heterocycle compounds utilized as pesticides and in pesticide discovery, highlighting their structure and biological properties. It summarizes relevant publications from the last 10 years, offering insights into the recent advancements in this field of research.

Technical Abstract: Isoxazolines are five-membered heterocycle compounds with a wide range of pharmacological and pesticidal activities. Numerous marketed pesticides contain an isoxazoline motif as key skeleton. Hence, the exploration of isoxazoline derivatives remains an important research area in pesticide discovery. This review provides an up-to-date overview of isoxazoline heterocycle compounds utilized as pesticides and in pesticide discovery, highlighting their structure and biological properties. It summarizes relevant publications from the last 10 years, offering insights into the recent advancements in this field of research.