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ARS Home » Northeast Area » Wyndmoor, Pennsylvania » Eastern Regional Research Center » Dairy and Functional Foods Research » Research » Publications at this Location » Publication #414745
Research Project: In vitro Human Gut System: Interactions Between Diet, Food Processing, and Microbiota

Location: Dairy and Functional Foods Research

Title: Too much of a good thing: Imposing an upper limit to a high fiber diet

Author
item Scarino Lemons, Johanna

Submitted to: Gastroenterology
Publication Type: Other
Publication Acceptance Date: 11/22/2023
Publication Date: 2/1/2024
Citation: Scarino Lemons, J.M. 2024. Too much of a good thing: Imposing an upper limit to a high fiber diet. Gastroenterology. 166(2): 250-51. https://doi.org/10.1053/j.gastro.2023.11.290.
DOI: https://doi.org/10.1053/j.gastro.2023.11.290

Interpretive Summary:

Technical Abstract: In this issue of Gastroenterology, Yang et al report the results of a series of studies investigating the effect of longterm high dietary fiber (20% cellulose plus 20% guar gum) intake in both spontaneous transgenic (Apcmin/+) and carcinogen-induced (azoxymethane) mouse models of CRC. The authors convincingly show that this mixed high-fiber diet increases colorectal tumor development in a microbiome dependent way. While the levels studied here are much higher than most Americans are actually consuming, this research may help to establish an upper limit to the recommended daily intake of soluble and insoluble fiber.