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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #414131
Research Project: Nutrition, Sarcopenia, Physical Function, and Skeletal Muscle Capacity During Aging

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Sarcopenia

Author
item SAYER, AVAN - Newcastle University
item COOPER, RACHEL - Newcastle University
item ARAI, HIDENORI - National Center For Geriatrics And Gerontology
item CAWTHON, PEGGY - University Of California San Francisco (UCSF)
item NTSAMA ESSOMBA, MARIE-JOSIANE - Centre Pasteur Du Cameroun
item FIELDING, ROGER - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item GROUNDS, MIRANDA - University Of Western Australia
item WITHAM, MILES - Newcastle University
item CRUZ-JENTOFT, ALFONSO - Hospital Ramon Y Cajal

Submitted to: Nature Aging
Publication Type: Review Article
Publication Acceptance Date: 8/12/2024
Publication Date: 9/19/2024
Citation: Sayer, A.A., Cooper, R., Arai, H., Cawthon, P.M., Ntsama Essomba, M., Fielding, R.A., Grounds, M., Witham, M.D., Cruz-Jentoft, A.J. 2024. Sarcopenia . Nature Aging. https://doi.org/10.1038/s41572-024-00550-w.
DOI: https://doi.org/10.1038/s41572-024-00550-w

Interpretive Summary:

Technical Abstract: Sarcopenia is the loss of skeletal mass and strength commonly, but not exclusively, associated with advancing age, that is observed across most species including humans. It can lead to decline in physical function and mobility as well as to increased risk of other adverse outcomes including falls, fractures, and premature mortality. Although estimates of prevalence vary resulting from use of different approaches to definition, even using a conservative approach, the prevalence is between 5 and 10% in the general population. Some of the most exciting research developments are currently happening in ageing skeletal muscle biology and harnessing progress in understanding the hallmarks of ageing has been key. There has been considerable convergence in approaches to diagnosis of sarcopenia over the last ten years with a growing emphasis on the central importance of muscle strength and function. Resistance exercise is currently the mainstay of treatment however it is not suitable for all, so there is an imperative to discover adjunctive and alternative treatments to improve quality of life. An internationally agreed approach to definition and diagnosis will allow a step change in the field and is likely to be available in the near future through the Global Leadership Initiative on Sarcopenia.