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ARS Home » Southeast Area » New Orleans, Louisiana » Southern Regional Research Center » Food Processing and Sensory Quality Research » Research » Publications at this Location » Publication #407594
Research Project: Nutritional Benefits of Health-Promoting Rice and Value-Added Foods

Location: Food Processing and Sensory Quality Research

Title: Xenohormetic phytochemicals inhibit neovascularization in microphysiological models of vasculogenesis and tumor angiogenesis

Author
item KPELI, WILLS - Tulane University
item CONCRAD, MICHAEL - Tulane University
item BRALOWER, WILLIAM - Tulane University
item BYRNE, ETHAN - Tulane University
item Boue, Stephen
item BURROW, MATTHEW - Tulane University
item MONDRINOS, MARK - Tulane University

Submitted to: Advanced Biology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 5/3/2024
Publication Date: 6/4/2024
Citation: Kpeli, W.G., Concrad, M.K., Bralower, W., Byrne, E.C., Boue, S.M., Burrow, M., Mondrinos, M.J. 2024. Xenohormetic phytochemicals inhibit neovascularization in microphysiological models of vasculogenesis and tumor angiogenesis. Advanced Biology. https://doi.org/10.1002/adbi.202300480.
DOI: https://doi.org/10.1002/adbi.202300480

Interpretive Summary: Phytochemicals possess proven health-promoting benefits. Xenohormesis proposes that phytochemicals produced to combat stress in plants may exert beneficial effects in animal cells Flavonoids (plant polyphenols) and phytoalexins made during plant stress modulate a range of human cell signaling mechanisms from sex hormone pathways to canonical kinase cascades, but there is a lack of robust systems for establishing functional correlations with human pathophysiology. We report potent inhibitory effects of grapefruit-derived Naringenin and soybean-derived Glyceollin in human cell models of bulk tissue vasculogenesis (blood vessel growth) and triple negative breast cancer (TNBC) tumor angiogenesis (inhibit the growth of blood vessel). The failure of cell culture assays to detect these bioeffects underscores the utility of our developed systems for resolving therapeutically relevant effects. Our study revealed differences in the response to Glyceollin and supports further research of Naringenin and Glyceollin as anti-angiogenic agents in personalized cancer therapy regimens.

Technical Abstract: Phytochemicals such as polyphenols possess proven health-promoting benefits. Xenohormesis proposes that phytochemicals produced to combat stressors in the host plant exert biochemical effects in animal cells lacking cognate receptors. Flavonoids and phytoalexins modulate a range of human cell signaling mechanisms from sex hormone pathways to canonical kinase cascades, but there is a lack of robust systems for establishing functional correlations with human pathophysiology. We report potent inhibitory effects of grapefruit-derived Naringenin and soybean-derived Glyceollin in human microphysiological models of bulk tissue vasculogenesis and triple negative breast cancer (TNBC) tumor angiogenesis configured for standardizable morphometric analysis of vascular architecture and sprouting dynamics. The failure of 2D culture assays to detect these bioeffects underscores the utility of microphysiological systems for resolving therapeutically relevant phytochemical effects. Our study revealed sex differences in the response to Glyceollin and supports further research of Naringenin and Glyceollin as anti-angiogenic agents in personalized cancer therapy regimens.