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ARS Home » Northeast Area » Beltsville, Maryland (BARC) » Beltsville Agricultural Research Center » Animal Genomics and Improvement Laboratory » Research » Publications at this Location » Publication #406779
Research Project: Improving Dairy Cow Feed Efficiency and Environmental Sustainability Using Genomics and Novel Technologies to Identify Physiological Contributions and Adaptations

Location: Animal Genomics and Improvement Laboratory

Title: A resource of longitudinal RNA-seq data of Holstein cow ruman, duodenum, and colon epithelial cells during the lactation cycle

Author
item GAO, YAHUI - University Of Maryland
item Liu, Ge
item MA, LI - University Of Maryland
item Li, Congjun
item Baldwin, Ransom

Submitted to: BMC Genomic Data
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 1/10/2025
Publication Date: 1/27/2025
Citation: Gao, Y., Liu, G., Ma, L., Li, C., Baldwin, R.L. 2025. A resource of longitudinal RNA-seq data of Holstein cow ruman, duodenum, and colon epithelial cells during the lactation cycle. BMC Genomic Data. 26. Article e9. https://doi.org/10.1186/s12863-025-01295-5.
DOI: https://doi.org/10.1186/s12863-025-01295-5

Interpretive Summary: Holstein cattle are one of the major ruminants that supply milk and dairy products to the human diet and agribusiness. To study the molecular basis of the adaption of dairy cattle for milk synthesis, we used RNA-seq to outline gene expression patterns in epithelial cells derived from three gastrointestinal tract tissues, including the rumen, duodenum, and colon at 8-time points. This resource will provide comprehensive insights into cattle lactation and reveal the specific characteristics of gastrointestinal tract tissues to understand the complexity of transcriptomic activities during lactation.

Technical Abstract: Holstein cattle are one of the major ruminants that supply milk and dairy products to the human diet and agribusiness. To investigate the molecular basis of the adaption of dairy cattle for milk synthesis, we used RNA-seq to profile gene expression patterns in epithelial cells derived from three gastrointestinal tract tissues, including the rumen, duodenum, and colon at 8-time points (Days 3, 14, 28, 45, 120, 220, 305, and the dry period). Overall, this resource will provide comprehensive insights into cattle lactation and reveal the specific characteristics of gastrointestinal tract tissues to understand the complexity of transcriptomic activities during lactation.