Location: Children's Nutrition Research CenterTitle: Editorial for the MCE special issue on "FXR and metabolism"
|KIM, KANG - University Of Texas Health Science Center|
|WOOTON-KEE, CLAVIA - Baylor College Of Medicine|
Submitted to: Molecular and Cellular Endocrinology
Publication Type: Other
Publication Acceptance Date: 2/10/2023
Publication Date: 4/5/2023
Citation: Kim, K.H., Wooton-Kee, C.R. 2023. Editorial for the MCE special issue on "FXR and metabolism". Molecular and Cellular Endocrinology. 565. Article 111889. https://doi.org/10.1016/j.mce.2023.111889.
Interpretive Summary: This editorial summarizes the different review articles contained in the Special Issue of Molecular and Cellular Endocrinology. This Special Issue was focused on the various roles of FXR in regulation of nutrient and metabolic homeostasis. FXR is a transcription factor that controls the expression of genes that control cholesterol, bile acid, glucose, and lipid levels in multiple tissues in the body. The utility of therapeutics targeting FXR was discussed in several of the articles.
Technical Abstract: Metabolic homeostasis is a tightly coordinated process to balance cellular nutrient requirements. The metabolic products derived from lipophilic precursors are ligands for a group of highly conserved transcription factors known as nuclear receptors. Nuclear receptors are comprised of a variable N-terminal region, a highly conserved zinc-finger containing DNA binding domain, a hinge region, and a ligand binding domain. The first nuclear receptors described were the steroid hormone nuclear receptors (estrogen receptor, glucocorticoid receptor), and the nuclear receptor field has expanded to encompass diverse areas of metabolism, including glucose and lipid metabolism, regulation of bile acid transport and synthesis, and immunology. The nuclear receptor farnesoid X receptor, FXR (NR1H4), has a central role in coordination of metabolism, particularly in the liver, intestine, and adipose tissue. The Special Issue: FXR and Metabolism review encompasses papers devoted to FXR in metabolism.