Exercise and behavior: adjuncts to pro-myogenic compounds for enhancing mobility in older adults

Authors: STORER, THOMAS - Brigham & Women'S Hospital; PAHOR, MARCO - University Of Florida; WOODHOUSE, LINDA - Tufts University; LACHMAN, MARGIE - Brandeis University; FIELDING, ROGER - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: Journal of Gerontology Medical Science
Publication Type: Review Article
Publication Acceptance Date: 1/31/2023
Publication Date: 6/16/2023
Citation: Storer, T.W., Pahor, M., Woodhouse, L., Lachman, M.E., Fielding, R.A. 2023. Exercise and behavior: adjuncts to pro-myogenic compounds for enhancing mobility in older adults. Journal of Gerontology Medical Science. https://doi.org/10.1093/gerona/glad041.
DOI: https://doi.org/10.1093/gerona/glad041

Interpretive Summary:

Technical Abstract: Background: Physical activity and exercise training exert multiple and varied effects on a wide array of tissues. Methods: Review of literature Results: The molecular mechanisms underlying the effects of exercise are being elucidated currently, in part by the work of the MOTr-PAC consortium. In addition to the basic biology of exercise, behavioral strategies are being examined with the goal of promoting exercise participation and sustaining adherence. Several unique approaches have targeted physical exercise as an effective therapy prior to orthopedic surgical procedures and in conjunction with pharmacological function promoting therapies. We summarize here recent progress on biological mechanisms of exercise training, behavioral approaches to exercise participation and the role exercise plays in recovery and in synergy with pharmacologic therapies with a particular focus on older adults. Conclusions: Physical activity and exercise training in multiple settings should serve as the baseline standard of care around which other therapeutic interventions should be considered when the goal is restoring or increasing physical functioning.