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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Food Safety and Enteric Pathogens Research » Research » Publications at this Location » Publication #399790

Research Project: Intestinal Microbial Ecology and Non-Antibiotic Strategies to Limit Shiga Toxin-Producing Escherichia coli (STEC) and Antimicrobial Resistance Transmission in Food Animals

Location: Food Safety and Enteric Pathogens Research

Title: Expression of short-chain fatty acid receptors and transporters in the porcine gastrointestinal tract

item BECKER, SAGE - Iowa State University
item WIARDA, JAYNE - Oak Ridge Institute For Science And Education (ORISE)
item LUETH, PAUL - Iowa State University
item Loving, Crystal

Submitted to: Conference Research Workers Disease Meeting
Publication Type: Abstract Only
Publication Acceptance Date: 1/20/2023
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Short-chain fatty acids (SCFAs) are microbiota-derived metabolites associated with increased intestinal barrier integrity and enhanced mucosal immunity. SCFAs signal via G protein-coupled receptors (GPCRs) expressed on the cell surface and/or inside the cell after transport into the cell via monocarboxylate (MCT) or Na-coupled monocarboxylate transporters (SMCT). Despite many studies investigating the impact of SCFAs on pig health and production, the distribution and localization of SCFA receptors and transporters in the pig gastrointestinal (GI) tract is minimally characterized.