|Dombrink Kurtzman, Mary Ann|
Submitted to: International Immunology Congress
Publication Type: Abstract Only
Publication Acceptance Date: 7/29/1995
Publication Date: N/A
Citation: Interpretive Summary:
Technical Abstract: Fusarium moniliforme and F. proliferatum, fungi frequently found as contaminants on corn, sorghum and other grains throughout the world, are capable of producing the mycotoxins, fumonisins, which have been associated with equine leukoencephalomalacia, porcine pulmonary edema and renal and hepatotoxicity in rats. Mortality and serological, hematological and pathological effects were observed in prior studies with broiler chicks fed F. proliferatum culture material containing known concentrations of fumonisin, moniliformin and beauvericin. When lymphocytes were incubated for 72 hours with 8 uM fumonisin B1 or 50 uM beauvericin, internucleosomal DNA fragmentation and morphological features characteristic of apoptosis were observed. Fumonisin B1 (IC50 = 1 uM), but not moniliformin, caused inhibition of proliferation. Hydrolyzed fumonisin B1 inhibited proliferation (IC50 = 0.1 uM) to a lesser degree following sonication (IC50 = 10 uM). In animals, these multiple toxins may interact synergistically.