Location: Genomics and Bioinformatics ResearchTitle: Gossypium hirsutum gene of unknown function, Gohir.A02G044702.1, encodes a potential B3 transcription factor of the REM subfamily
|ALLEN, MICHAEL - Western Carolina University|
|STORM, AMANDA - Western Carolina University|
Submitted to: microPublication Biology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 7/26/2022
Publication Date: 8/5/2022
Citation: Allen, M., Hulse-Kemp, A.M., Storm, A.R. 2022. Gossypium hirsutum gene of unknown function, Gohir.A02G044702.1, encodes a potential B3 transcription factor of the REM subfamily. microPublication Biology. https://doi.org/10.17912/micropub.biology.000574.
Interpretive Summary: Multiple high-quality genomes are available for cotton, the most important producer of natural fibers for textiles. Genes identified in these genomes have been computationally identified, but determining the function of the genes has been difficult and a large number of these (approximately 20%) remain classified as unknown function. Manual curation and investigation of one gene of unknown function has identified a potential function of a transcription factor. This investigation was performed as a part of a collaborative effort of USDA-ARS with Western Carolina University undergraduate students as the topic of a semester research project.
Technical Abstract: A gene of unknown function, Gohir.A02G044702.1, identified in Gossypium hirsutum was studied using sequence and structure bioinformatic tools. The encoded protein (UniProt A0A1U8MGX4), predicted to localize to the nucleus, was found to retain the B3 transcription factor domain with conserved DNA-binding residues and to most closely cluster with REM subfamily members of B3-domain containing proteins.