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ARS Home » Southeast Area » Stoneville, Mississippi » Pollinator Health in Southern Crop Ecosystems Research » Research » Publications at this Location » Publication #394620
Research Project: Ecological Assessment and Mitigation Strategies to Reduce the Risks of Bees to Stressors in Southern Crop Ecosystems

Location: Pollinator Health in Southern Crop Ecosystems Research

Title: Tetraspanin CD82 Regulates S100A7 Expression in Oral Squamous Cell Carcinoma

Author
item Zhang, Weiqiang
item REDDI, KIRAN - University Of Tennessee
item SHAHRABI-FARAHANI, SHOKOUFEH - University Of Tennessee
item ANDERSON, KENNETH - University Of Tennessee
item LIU, MINGYUE - University Of Tennessee
item ROSE, LORNE - University Of Tennessee
item KAKHNIASHVILI, DAVID - University Of Tennessee
item WANG, XUSHENG - University Of North Dakota
item ZHANG, YANHUI - University Of Tennessee

Submitted to: Cancer Cell International
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 2/17/2024
Publication Date: 2/24/2024
Citation: Zhang, W., Reddi, K.K., Shahrabi-Farahani, S., Anderson, K.M., Liu, M., Rose, L., Kakhniashvili, D., Wang, X., Zhang, Y. 2024. Tetraspanin CD82 Regulates S100A7 Expression in Oral Squamous Cell Carcinoma. Cancer Cell International. 25(5)/2569. https://doi.org/10.3390/ijms25052659.
DOI: https://doi.org/10.3390/ijms25052659

Interpretive Summary: Oral cancer patients have low survival rate and poor quality of life. Currently, limited information is available regarding the role of CD82 in oral squamous cell carcinoma, which is the most common oral cancer. In this study, we used oral cancer cells and tissues to study the expression level of CD82, its function, and its mechanism of action. We found that (1) CD82 has varying expression level in different oral cancel types; (2) CD82 regulates cancer cell migration; and (3) CD82 regulates the expression level of some S100 family proteins. The association of CD82 and S100 family proteins in oral cancers is a new discovery that could contribute to discovery of new biomarkers for disease diagnosis and monitoring, and identification of new therapeutic targets.

Technical Abstract: Oral cancer patients have low survival rate and poor quality of life. Oral squamous cell carcinoma (OSCC) is the most common malignant oral cavity cancer. Currently, limited information is available regarding the role of CD82 in OSCC. Here, we sought to investigate the expression level and role of CD82 in OSCC and the underlying molecular mechanism using two OSCC cell lines (CAL 27 and SCC-25), OSCC tissues, and normal human gingival epithelial cells (S-G). Our data showed that CD82 has varying expression level in these OSCC cells and plays a regulatory role in cell migration. Furthermore, CD82 regulates the expression of S100A7 and some other S100 family proteins including S100A7A, S100A6, S100A8, and S100A9 in all 3 cell types tested. The association of CD82 and S100 family proteins in OSCC could constitute a previously unrecognized mechanism through which CD82 regulates the pathology of metastatic OSCC cells.