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ARS Home » Southeast Area » New Orleans, Louisiana » Southern Regional Research Center » Commodity Utilization Research » Research » Publications at this Location » Publication #387330

Research Project: Development of Novel Cottonseed Products and Processes

Location: Commodity Utilization Research

Title: Differential response of fasting and postprandial angiopoietin-like proteins 3, -4, and -8 to cottonseed oil versus olive oil

item KAVIANI, SEPIDEH - University Of Georgia
item POLLEY, KRISTINE - University Of Georgia
item Dowd, Michael
item COOPER, JAMIE - University Of Georgia
item PATON, CHAD - University Of Georgia

Submitted to: Journal of Functional Foods
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 10/14/2021
Publication Date: 10/16/2021
Citation: Kaviani, S., Polley, K.R., Dowd, M.K., Cooper, J.A., Paton, C.M. 2021. Differential response of fasting and postprandial angiopoietin-like proteins 3, -4, and -8 to cottonseed oil versus olive oil. Journal of Functional Foods. 87:104802

Interpretive Summary: Dietary inclusion of cottonseed oil has been shown to modify lipid profiles and slow the uptake of fatty materials in the liver, whereas other oils do not exhibit the same effect. A series of angiopoietin-like proteins have been identified that regulate the uptake and utilization of fats by muscle and adipose (fat storage) tissues. To better understand the reasons that cottonseed oil alters lipid profiles, a study was conducted to see if diets rich in cottonseed oil affected the levels of the angiopoietin-like proteins. Significant differences were found between the response of these regulatory facts for human subjects fed cottonseed and olive oils. The work should be of interest to researchers studying the factors that regulate the use and storage of lipids in the human body.

Technical Abstract: Angiopoietin-like proteins (ANGPTL) 3, -4 and -8 regulate lipid metabolism by altering lipoprotein lipase activity, but it is not known how cottonseed oil (CSO) differentially affects postprandial responses of ANGPTL’s in humans. We compared the effect of a diet rich in either CSO or olive oil (OO) on fasting and postprandial ANGPTL’s. Fifteen males completed two feeding trials in random order: 1) a CSO-rich diet and 2) an OO-rich diet with fasting and postprandial blood samples collected pre-diet at visit 1 (v1) followed by a 5-day feeding trial and a post-diet visit (v2) identical to v1 and a 2-4 week washout period. Fasting ANGPTL4 and ANGPTL8 decreased from v1 to v2 after the CSO diet and increased with the OO diet. Postprandial ANGPTL3, -4, and -8 were lower following the CSO meal. The lipid-lowering effects of CSO may be mediated by reduced fasting and postprandial ANGPTL3, -4 and -8 responses.